Heat Vision and Jack is a Fox TV pilot from 1999 almost too surreal to believe:

Written by Dan Harmon and Rob Schrab, directed by Ben Stiller, this series was passed over by Fox despite critical acclaim from those who've been lucky enough to see it.

The 30 minute pilot is about an astronaut (played by Jack Black) with a medical secret who is on the run from the evil Ron Silver and the rest of NASA, with the help of a talking motorcycle called Heat Vision (voiced by Owen Wilson).

Someone was kind enough to post the entire pilot episode to YouTube, which you can view in the embedded player below. I had heard of this but never seen it, so this was quite a find...